Dyslipidemia Induced Endothelial Stiffening is Accompanied by Increased Membrane Tension

Stiffening of Compressor Shells by Tension Rings

Membrane tension lowering induced by protein activity.

Using videomicroscopy we present measurements of the fluctuation spectrum of giant vesicles containing bacteriorhodopsin pumps. When the pumps are activated, we observe a significant increase of the fluctuations in the low wave vector region, which we interpret as due to a lowering of the effective tension of the membrane.

Exercise-induced myocardial ischemia is accompanied by increased serum creatine concentrations.

References 1. Brusilow SW, Maestri NE. Urea cycle disorders: diagnosis, pathophysiology, and therapy. Adv Pediatr 1996;43:127–70. 2. Batshaw ML, Robinson MB, Ye X, Pabin C, Daikhin Y, Burton BK, et al. Correction of ureagenesis after gene transfer in an animal model and after liver transplantation in humans with ornithine transcarbamylase deficiency. Pediatr Res 1999;46:588–93. 3. Batshaw ML, B...

Ouabain-induced hypertension is accompanied by increases in endothelial vasodilator factors.

The involvement of nitric oxide (NO), prostaglandins, and calcium-dependent potassium channel (K(Ca)) activators on the negative modulation of phenylephrine-induced contractions was evaluated on the isolated aorta and caudal (CAU) artery obtained from rats treated with ouabain for 5 wk to induce hypertension. In ouabain-treated rats, the reactivity to phenylephrine was reduced in the endotheliu...

Channel by Membrane Tension

The sensitivity of abg rat epithelial Na 1 channel (rENaC) to osmotically or mechanically induced changes of membrane tension was investigated in the Xenopus oocyte expression system, using both dual electrode voltage clamp and cell-attached patch clamp methodologies. ENaC whole-cell currents were insensitive to mechanical cell swelling caused by direct injection of 90 or 180 nl of 100-mM KCl. ...